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Analysis of institutional authors

Sebastian, DavidCorresponding AuthorBeltrà, MarcAuthorIrazoki, AndreaAuthorPalacin, ManuelAuthorZorzano, AntonioCorresponding Author

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April 7, 2024
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TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

Publicated to: Autophagy. 20 (8): 1815-1824 - 2024-03-29 20(8), DOI: 10.1080/15548627.2024.2333717

Authors:

Sebastian, D; Beltra, M; Irazoki, A; Sala, D; Aparicio, P; Aris, C; Alibakhshi, E; Rubio-Valera, M; Palacin, M; Castellanos, J; Lores, L; Zorzano, A
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Affiliations

Avid Biosci Inc, San Diego, CA 92121 USA - Author
Baqyiatallah Univ Med Sci, Baqyiatallah Hosp, Phys Med & Rehabil Dept, Clin Res Dev Unit,Fac Med, Tehran, Iran - Author
Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Baldiri Reixac 10-12, Barcelona 08028, Spain - Author
Hosp St Boi St Joan Deu, Dept Family & Community Med, Barcelona, Spain - Author
Hosp St Boi St Joan Deu, Dept Orthoped Surg & Traumatol, Barcelona, Spain - Author
Hosp St Boi St Joan Deu, Pneumol Dept, Barcelona, Spain - Author
Hosp St Boi St Joan Deu, Qual & Patient Safety Unit, Barcelona, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Enfermedades Raras CIBERER, Madrid, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Epidemiol & Salud Publ CIBERESP, Madrid, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain - Author
Institute for Research in Biomedicine - Author
Univ Barcelona, Dept Bioquim & Biomed Mol, Fac Biol, Barcelona, Spain - Author
Univ Barcelona, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain - Author
Univ Copenhagen, Dept Biomed Sci BMI, Copenhagen, Denmark - Author
Univ Tehran Med Sci, Adv Med Technol & Equipment Inst, Res Ctr Mol & Cellular Imaging, Quantitat MR Imaging & Spect Grp, Tehran, Iran - Author
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Abstract

Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed. Here we show that the autophagy regulator TP53INP2/TRP53INP2 is decreased during aging in mouse and human skeletal muscle. Importantly, chronic activation of autophagy by muscle-specific overexpression of TRP53INP2 prevents sarcopenia and the decline of muscle function in mice. Acute re-expression of TRP53INP2 in aged mice also improves muscle atrophy, enhances mitophagy, and reduces ROS production. In humans, high levels of TP53INP2 in muscle are associated with increased muscle strength and healthy aging. Our findings highlight the relevance of an active muscle autophagy in the maintenance of muscle mass and prevention of sarcopenia.Abbreviation: ATG7: autophagy related 7; BMI: body mass index; EIF4EBP1: eukaryotic translation initiation factor 4E binding protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; ROS: reactive oxygen species; TP53INP2: tumor protein p53 inducible nuclear protein 2; WT: wild type
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Keywords

AgingAutophagyImpaired autophagyMitochondrialMitophagyMuscle atrophySarcopenia

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Autophagy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 16/204, thus managing to position itself as a Q1 (Primer Cuartil), in the category Cell Biology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-02-02:

  • WoS: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-02-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 14.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 100.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 26 (Altmetric).
  • The number of mentions in news outlets: 10 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/2445/211461
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Denmark; Iran; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Sebastián Muñoz, David) and Last Author (Zorzano Olarte, Antonio).

the authors responsible for correspondence tasks have been Sebastián Muñoz, David and Zorzano Olarte, Antonio.

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Awards linked to the item

The work was supported by the European Foundation for the Study of Diabetes Fundacio la Marato de TV3 Fundacion BBVA Fundacion Ramon Areces Instituto de Salud Carlos III Ministerio de Ciencia e Innovacion.
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